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Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

null

《医学前沿（英文）》 2015年第9卷第1期页码 72-76 doi: 10.1007/s11684-014-0347-x

摘要：

Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91±143.89 ng/ml and 348.26±202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P<0.001; for CAL, r = 0.54, P<0.001; for GI, r = 0.49, P<0.001; and for PI, r = 0.63, P<0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

关键词： matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index

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Investigating the raveling test for full-depth reclamation

Robert HILL, Andrew BRAHAM

《结构与土木工程前沿（英文）》 2018年第12卷第2期页码 222-226 doi: 10.1007/s11709-017-0423-9

摘要： Full-Depth Reclamation (FDR) is a sustainable method of building pavement structure compared to more traditional rehabilitation methods. Traffic is generally returned to an FDR project before a surface course is applied, as water in the FDR needs time to evaporate from the structure. This should not be done too quickly or raveling occurs. Currently, there is no test to quantify the timing of return to traffic. In this study, the “Raveling test of cold mixed bituminous emulsion samples” (ASTM D7196) was used to compare asphalt emulsion and asphalt foam FDR. Asphalt emulsion samples were cured at ambient and 40 °C temperatures, while asphalt foam samples were cured at ambient temperatures. Raveling test data was collected from 0 to 48 hours of curing, however, samples were often not able to withstand fifteen minutes of testing. Therefore, the “time lasted” (the time the raveling head loses contact with the surface of the sample) was recorded. In general, the asphalt emulsion samples that were cured in the oven at 40 °C had a longer time lasted and showed higher potential for determination of return to traffic. In addition, the asphalt emulsion samples had a longer time lasted than the asphalt foam samples at ambient temperatures.

关键词： raveling full depth reclamation

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Multivariable regression model for Fox depth correction factor

Ravi Kant MITTAL, Sanket RAWAT, Piyush BANSAL

《结构与土木工程前沿（英文）》 2019年第13卷第1期页码 103-109 doi: 10.1007/s11709-018-0474-6

摘要： This paper presents a simple and efficient equation for calculating the Fox depth correction factor used in computation of settlement reduction due to foundation embedment. Classical solution of Boussinesq theory was used originally to develop the Fox depth correction factor equations which were rather complex in nature. The equations were later simplified in the form of graphs and tables and referred in various international code of practices and standard texts for an unsophisticated and quick analysis. However, these tables and graphs provide the factor only for limited values of the input variables and hence again complicates the process of automation of analysis. Therefore, this paper presents a non-linear regression model for the analysis of effect of embedment developed using “IBM Statistical Package for the Social Sciences” software. Through multiple iterations, the value of coefficient of determination is found to reach 0.987. The equation is straightforward, competent and easy to use for both manual and automated calculation of the Fox depth correction factor for wide range of input values. Using the developed equation, parametric study is also conducted in the later part of the paper to analyse the extent of effect of a particular variable on the Fox depth factor.

关键词： settlement embedment Fox depth correction factor regression multivariable

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Particle swarm optimization model to predict scour depth around a bridge pier

Shahaboddin SHAMSHIRBAND, Amir MOSAVI, Timon RABCZUK

《结构与土木工程前沿（英文）》 2020年第14卷第4期页码 855-866 doi: 10.1007/s11709-020-0619-2

摘要： Scour depth around bridge piers plays a vital role in the safety and stability of the bridges. The former approaches used in the prediction of scour depth are based on regression models or black box models in which the first one lacks enough accuracy while the later one does not provide a clear mathematical expression to easily employ it for other situations or cases. Therefore, this paper aims to develop new equations using particle swarm optimization as a metaheuristic approach to predict scour depth around bridge piers. To improve the efficiency of the proposed model, individual equations are derived for laboratory and field data. Moreover, sensitivity analysis is conducted to achieve the most effective parameters in the estimation of scour depth for both experimental and filed data sets. Comparing the results of the proposed model with those of existing regression-based equations reveal the superiority of the proposed method in terms of accuracy and uncertainty. Moreover, the ratio of pier width to flow depth and ratio of 50 (mean particle diameter) to flow depth for the laboratory and field data were recognized as the most effective parameters, respectively. The derived equations can be used as a suitable proxy to estimate scour depth in both experimental and prototype scales.

关键词： scour depth bridge design and construction particle swarm optimization computational mechanics artificial intelligence bridge pier

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Depth of cut models for multipass abrasive waterjet cutting of alumina ceramics with nozzle oscillation

Jun WANG

《机械工程前沿（英文）》 2010年第5卷第1期页码 19-32 doi: 10.1007/s11465-009-0082-1

摘要： An experimental study of the depth of cut in multipass abrasive waterjet (AWJ) cutting of alumina ceramics with controlled nozzle oscillation is presented. It is found that this cutting technique can significantly increase the depth of cut by an average of 50.8% as compared to single pass cutting without nozzle oscillation under the corresponding cutting conditions and within the same cutting time. Predictive models for the depth of cut are then developed. The modelling process starts with single pass cutting using a dimensional analysis technique and the particle erosion theories applied to alumina ceramics, before progressing to the development of the models for multipass cutting. The models are finally assessed both qualitatively and quantitatively with experimental data. It is shown that the model predictions are in good agreement with the experimental data with the average deviations of about 1%.

关键词： abrasive waterjet engineering ceramics depth of cut cutting performance nozzle oscillation machining

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Effect of biological activated carbon filter depth and backwashing process on transformation of biofilm

Wanqi Qi, Weiying Li, Junpeng Zhang, Xuan Wu, Jie Zhang, Wei Zhang

《环境科学与工程前沿（英文）》 2019年第13卷第1期 doi: 10.1007/s11783-019-1100-0

摘要：

We studied BAC biofilm during the process of initial operation and backwash.

Microbial diversity decreased gradually with the increase of BAC filter depth.

Proteobacteria dominated at the phylum level among the BAC biofilm samples.

α-proteobacteria increased about 10% in all carbon filter depth after backwash.

关键词： Biological activated carbon Biofilm Community structure Carbon filter depth High-throughput sequencing

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Probing the redox process of

Rui Lu, Wei Chen, Wen-Wei Li, Guo-Ping Sheng, Lian-Jun Wang, Han-Qing Yu

《环境科学与工程前沿（英文）》 2017年第11卷第1期 doi: 10.1007/s11783-017-0905-y

摘要： Fluorescece spectroelectrochemistry is used to probe redox process of benzoquinone. The benzoquinone reduction state has a lower fluorescence quantum efficiency. CVF and DCVF can reveal more information about benzoquinone redox reactions. This method can analyze compounds with fluorescence and electrochemical activities. Quinones are common organic compounds frequently used as model dissolved organic matters in water, and their redox properties are usually characterized by either electrochemical or spectroscopic methods separately. In this work, electrochemical methodology was combined with two fluorescence spectroelectrochemical techniques, cyclic volta- fluorescence spectrometry (CVF) and derivative cyclic volta- fluorescence spectrometry (DCVF), to determine the electrochemical properties of -benzoquinone in dimethyl sulfoxide, an aprotic solution. The CVF results show that the electrochemical reduction of -benzoquinone resulted in the formation of radical anion and dianion, which exhibited a lower fluorescence intensity and red-shift of the emission spectra compared to that of -benzoquinone. The fluorescence intensity was found to vary along with the electrochemical oxidation and reduction of -benzoquinone. The CVF and DCVF results were in good consistence. Thus, the combined method offers a powerful tool to investigate the electrochemical process of -benzoquinone and other natural organic compounds.

关键词： p-Benzoquinone Electrochemistry Fluorescence Spectroelectrochemistry Derivative cyclic volta fluorescence

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Capturing the opportunities to initiate an in-depth integration of traditional Chinese medicine and western

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《医学前沿（英文）》 2014年第8卷第3期页码 268-271 doi: 10.1007/s11684-014-0369-4

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Prediction of hydro-suction dredging depth using data-driven methods

《结构与土木工程前沿（英文）》 2021年第15卷第3期页码 652-664 doi: 10.1007/s11709-021-0719-7

摘要： In this study, data-driven methods (DDMs) including different kinds of group method of data handling (GMDH) hybrid models with particle swarm optimization (PSO) and Henry gas solubility optimization (HGSO) methods, and simple equations methods were applied to simulate the maximum hydro-suction dredging depth (h_s). Sixty-seven experiments were conducted under different hydraulic conditions to measure the h_s. Also, 33 data samples from three previous studies were used. The model input variables consisted of pipeline diameter (d), the distance between the pipe inlet and sediment level (Z), the velocity of flow passing through the pipeline (u₀), the water head (H), and the medium size of particles (D₅₀). Data-driven simulation results indicated that the HGSO algorithm accurately trains the GMDH methods better than the PSO algorithm, whereas the PSO algorithm trained simple simulation equations more precisely. Among all used DDMs, the integrative GMDH-HGSO algorithm provided the highest accuracy (RMSE = 7.086 mm). The results also showed that the integrative GMDHs enhance the accuracy of polynomial GMDHs by ~14.65% (based on the RMSE).

关键词： sedimentation water resources dam engineering machine learning heuristic

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Probing the Interfacial Forces and Surface Interaction Mechanisms in Petroleum Production"> Erratum to "Probing the Interfacial Forces and Surface Interaction Mechanisms in Petroleum Production Erratum

Diling Yang,Xuwen Peng,Qiongyao Peng,Tao Wang,Chenyu Qiao,Ziqian Zhao,Lu Gong,Yueliang Liu,Hao Zhang,Hongbo Zeng

《工程（英文）》 2023年第22卷第3期页码 233-233 doi: 10.1016/j.eng.2023.02.001

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Probing the catalytic activity of M-N

Fan Ge, Qingan Qiao, Xin Chen, You Wu

《化学科学与工程前沿（英文）》 2021年第15卷第5期页码 1206-1216 doi: 10.1007/s11705-020-2017-7

摘要： In this work, the detailed oxygen reduction reaction (ORR) catalytic performance of M-N O (M= Fe, Co, and Ni; = 1–4) has been explored via the detailed density functional theory method. The results suggest that the formation energy of M-N O shows a good linear relationship with the number of doped O atoms. The adsorption manner of O on M-N O changed from end-on ( = 1 and 2) to side-on ( = 3 and 4), and the adsorption strength gradually increased. Based on the results for binding strength of ORR intermediates and the Gibbs free energy of ORR steps on the studied catalysts, we screened out two highly active ORR catalysts, namely Co-N O and Ni-N O , which possess very small overpotentials of 0.27 and 0.32 V, respectively. Such activities are higher than the precious Pt catalyst. Electronic structure analysis reveals one of the reasons for the higher activity of Co-N O and Ni-N O is that they have small energy gaps and moderate highest occupied molecular orbital energy levels. Furthermore, the results of the density of states reveal that the O doping can improve the electronic structure of the original catalyst to tune the adsorption of the ORR intermediates.

关键词： M-N-C catalyst oxygen doping oxygen reduction reaction catalytic activity density functional theory

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Carbonation depth prediction of fly ash concrete subjected to 2- and 3-dimensional CO attack

CHEN Shudong, SUN Wei, ZHANG Yunsheng, GUO Fei

《结构与土木工程前沿（英文）》 2008年第2卷第4期页码 395-400 doi: 10.1007/s11709-008-0046-2

摘要： Based on accelerated carbonation test, 1D, 2D and 3D carbonation of high performance concrete with different fly ash contents (0%, 15%, 20%, 40%, 60%) were studied. The interaction coefficients of 2D and 3D carbonation are defined. The time-dependent coefficient of carbon dioxide diffusion and the interaction coefficients of 2D and 3D carbonation are analyzed. The mathematical model which includes and is deduced. The experiments indicate that 2D and 3D carbonation have obvious interaction. Interaction coefficients obey the attenuation function through time . The mathematical model of 2D and 3D carbonation life prediction based on Fick scattering law can be solved by Fourier expansion. The life prediction of concrete of Sutong Bridge beam shows that the 1D, 2D, 3D carbonation prediction life are 1595 a, 882 a and 758 a, respectively, 2D and 3D carbonation life predicted are reduced clearly.

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An experimental study on plunging depth of density currents

Hassan GOLEIJ, Amir Hamzeh HAGHIABI, Abbas PARSAIE

《结构与土木工程前沿（英文）》 2017年第11卷第4期页码 388-395 doi: 10.1007/s11709-017-0417-7

摘要： Mass density of the current flows is the one of the important problem in the hydraulics of the dam reservoir. Plunge point occurs when the mass density current penetrates in the stagnant fluid. Recognition the place of this point is very important because of clearing the boundary of the density current flow and ambient fluid. In this study the influences of bed slope and hydraulic parameters on plunging depth were experimentally investigated. The results show that the slope has a minor effect on the plunging depth. The height of plunging depth is increased by increasing the density of the current flow. Also increasing the densimetric Froude number caused of decreasing the plunging depth. Finally an equation was proposed to estimate the plunging depth using as function of flow characteristics.

关键词： dense current plunge point Densimetric Froude Number dam reservoirs

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基于抗浮稳定的盾构隧道合理覆土厚度研究

刘学彦,袁大军,姜曦

《中国工程科学》 2015年第17卷第1期页码 88-95

摘要：

运用理论分析和数值计算相结合的方法，分别从施工期和运营期角度提出了隧道抗浮稳定合理覆土厚度设定原则和理论计算方法；对于隧道施工期，考虑土体侧向摩阻力和管片环间摩阻力的影响等较为有利因素，同时考虑未凝浆液的影响等不利因素，建立了合理覆土厚度的理论计算公式；对于隧道运营期，建议只考虑隧道上覆土体自重进行抗浮，对于存在洪水冲刷的隧道设计，其上覆土体厚度还要加上设计冲刷深度；为南京某在建隧道的纵断面设计提供了一定的参考，同时也为其他过江海盾构隧道满足抗浮稳定的覆土厚度设定提供理论支持。

关键词：抗浮安全；隧道施工期；隧道运营期；覆土厚度

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Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

《工程（英文）》 doi: 10.1016/j.eng.2023.02.016

摘要： As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent that glycans’ immense complexity cannot be ignored. To fully delineate glycan structures, we developed an integrative approach combining a set of cost-effective, widespread, and easy-to-handle analytical methods. The key feature of our workflow is the exploitation of a removable fluorescent label—exemplified by 9-fluorenylmethyl chloroformate (Fmoc)—to bridge the gap between diverse glycoanalytical methods, especially multiplexed capillary gel electrophoresis with laser-induced fluorescence detection (xCGE-LIF) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Through the detailed structural analysis of selected, dauntingly complex N-glycans from chicken ovalbumin, horse serum, and bovine transferrin, we illustrate the capabilities of the presented strategy. Moreover, this approach “visualizes” N-glycans that have been difficult to identify thus far—such as the sulfated glycans on human immunoglobulin A—including minute changes in glycan structures, potentially providing useful new targets for biomarker discovery.

关键词： Glycoproteins N-glycans Reversible labeling Hydrophilic interaction liquid chromatography Capillary gel electrophoresis Mass spectrometry